Reaction: ATP + D-tagatopyranose 1-phosphate = ADP + D-tagatopyranose 1,6-bisphosphate
Other name(s): TagK
Systematic name: ATP:D-tagatose-1-phosphate 6-phosphotransferase
Comments: The enzyme, which has been purified from the bacteria Klebsiella oxytoca and Bacillus licheniformis, is part of a D-tagatose catabolic pathway. The substrate, which occurs in a pyranose form in solution, undergoes a change to the furanose conformation after binding to the enzyme, in order to permit phosphorylation at C-6.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Shakeri-Garakani, A., Brinkkotter, A., Schmid, K., Turgut, S. and Lengeler, J.W. The genes and enzymes for the catabolism of galactitol, D-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution. Mol. Genet. Genomics 271 (2004) 717Ð728. [PMID: 15257457]
2. Van der Heiden, E., Delmarcelle, M., Lebrun, S., Freichels, R., Brans, A., Vastenavond, C.M., Galleni, M. and Joris, B. A pathway closely related to the D-tagatose pathway of gram-negative enterobacteria identified in the gram-positive bacterium Bacillus licheniformis. Appl. Environ. Microbiol. 79 (2013) 3511Ð3515. [PMID: 23524682]
1. Van der Heiden, E., Delmarcelle, M., Simon, P., Counson, M., Galleni, M., Freedberg, D.I., Thompson, J., Joris, B. and Battistel, M.D. Synthesis and physicochemical characterization of D-tagatose-1-phosphate: the substrate of the tagatose-1-phosphate kinase in the phosphotransferase system-mediated D-tagatose catabolic pathway of Bacillus licheniformis, J. Mol. Microbiol. Biotechnol. 25 (2015) 106-119. [PMID: 26159072]