IUBMB Enzyme Nomenclature

EC 2.7.1.228

Accepted name: mannosyl-inositol-phosphoceramide inositolphosphotransferase

Reaction: 1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide

Glossary: a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosyl-diphosphoinositol-α-hydroxyphytoceramide = MIP2C

Other name(s): IPT1 (gene name)

Systematic name: 1-phosphatidyl-1D-myo-inositol:mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide phosphoinositoltransferase

Comments: This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-α-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).

References:

1. Dickson, R.C., Nagiec, E.E., Wells, G.B., Nagiec, M.M. and Lester, R.L. Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem 272 (1997) 29620-29625. [PMID: 9368028]

[EC 2.7.1.228 created 2019]


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