IUBMB Enzyme Nomenclature

EC 2.7.1.227

Accepted name: inositol phosphorylceramide synthase

Reaction: 1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytocermide = 1,2-diacyl-sn-glycerol + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide

Glossary: a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain inositol phospho-α-hydroxyphytoceramide = IPC

Other name(s): AUR1 (gene name); KEI1 (gene name)

Systematic name: 1-phosphatidyl-1D-myo-inositol:(2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase

Comments: The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to α-hydroxyphytoceramides, generating a very-long-chain inositol phospho-α hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.

References:

1. Nagiec, M.M., Nagiec, E.E., Baltisberger, J.A., Wells, G.B., Lester, R.L. and Dickson, R.C. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem 272 (1997) 9809-9817. [PMID: 9092515]

2. Levine, T.P., Wiggins, C.A. and Munro, S. Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol. Biol. Cell 11 (2000) 2267-2281. [PMID: 10888667]

3. Sato, K., Noda, Y. and Yoda, K. Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol. Biol. Cell 20 (2009) 4444-4457. [PMID: 19726565]

[EC 2.7.1.227 created 2019]


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