IUBMB Enzyme Nomenclature

EC 2.7.1.223

Accepted name: aminoimidazole riboside kinase

Reaction: ATP + 5-amino-1-(β-D-ribosyl)imidazole = ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole

Other name(s): STM4066 (locus name)

Systematic name: ATP:5-amino-1-(β-D-ribosyl)imidazole 5'-phosphotransferase

Comments: The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(β-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-β-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Dougherty, M. and Downs, D.M. The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. J. Bacteriol. 185 (2003) 332-339. [PMID: 12486071]

2. Zhang, Y., Dougherty, M., Downs, D.M. and Ealick, S.E. Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure 12 (2004) 1809-1821. [PMID: 15458630]

[EC 2.7.1.223 created 2018]


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