IUBMB Enzyme Nomenclature

EC 2.7.1.187

Accepted name: acarbose 7IV-phosphotransferase

Reaction: ATP + acarbose = ADP + acarbose 7IV-phosphate

Glossary: acarbose = 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino}-α-D-glucopyranosyl-(1→4)-α-D-glucopyranosyl-(1→4)-β-D-glucopyranose

Other name(s): acarbose 7-kinase; AcbK

Systematic name: ATP:acarbose 7IV-phosphotransferase

Comments: The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Drepper, A. and Pape, H. Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function. J. Antibiot. (Tokyo) 49 (1996) 664-668. [PMID: 8784428]

2. Goeke, K., Drepper, A. and Pape, H. Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp. J. Antibiot. (Tokyo) 49 (1996) 661-663. [PMID: 8784426]

3. Zhang, C.S., Stratmann, A., Block, O., Bruckner, R., Podeschwa, M., Altenbach, H.J., Wehmeier, U.F. and Piepersberg, W. Biosynthesis of the C7-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. J. Biol. Chem. 277 (2002) 22853-22862. [PMID: 11937512]

[EC 2.7.1.187 created 2015]


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