IUBMB Enzyme Nomenclature

EC 2.7.1.185

Accepted name: mevalonate 3-kinase

Reaction: ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate

For diagram of reaction click here.

Other name(s): ATP:(R)-MVA 3-phosphotransferase

Systematic name: ATP:(R)-mevalonate 3-phosphotransferase

Comments: Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Vinokur, J.M., Korman, T.P., Cao, Z. and Bowie, J.U. Evidence of a novel mevalonate pathway in archaea. Biochemistry 53 (2014) 4161-4168. [PMID: 24914732]

2. Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. and Hemmi, H. (R)-Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J. Biol. Chem. 289 (2014) 15957-15967. [PMID: 24755225]

[EC 2.7.1.185 created 2014]


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