IUBMB Enzyme Nomenclature

EC 2.6.1.79

Accepted name: glutamate—prephenate aminotransferase

Reaction: L-arogenate + 2-oxoglutarate = prephenate + L-glutamate

For diagram click here, or click here (mechanism)

Other name(s): prephenate transaminase (ambiguous); PAT (ambiguous); L-glutamate:prephenate aminotransferase

Systematic name: L-arogenate:2-oxoglutarate aminotransferase

Comments: A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate—prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Bonner, C.A. and Jensen, R.A. Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris. Arch. Biochem. Biophys. 238 (1985) 237-246. [PMID: 3985619]

2. Siehl, D.L., Connelly, J.A. and Conn, E.E. Tyrosine biosynthesis in Sorghum bicolor: characteristics of prephenate aminotransferase. Z. Naturforsch. [C] 41 (1986) 79-86. [PMID: 2939644]

3. Bonner, C. and Jensen, R. Prephenate aminotransferase. Methods Enzymol. 142 (1987) 479-487. [PMID: 3298985]

[EC 2.6.1.79 created 2005]


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