IUBMB Enzyme Nomenclature

EC 2.6.1.23

Accepted name: 4-hydroxyglutamate transaminase

Reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate

For diagram click here (mechanism).

Other name(s): 4-hydroxyglutamate aminotransferase

Systematic name: 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase

Comments: Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37277-86-4

References:

1. Goldstone, A. and Adams, E. Metabolism of γ-hydroxyglutamic acid. I. Conversion to α-hydroxy-γ-ketoglutarate by purified glutamic-aspartic transaminase to rat liver. J. Biol. Chem. 237 (1962) 3476-3485. [PMID: 13948827]

2. Kuratomi, K., Fukunaga, K. and Kobayashi, Y. The metabolism of γ-hydroxyglutamate in rat liver. II. A transaminase concerned in γ-hydroxyglutamate metabolism. Biochim. Biophys. Acta 78 (1963) 629-636.

[EC 2.6.1.23 created 1972, modified 1982]


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