IUBMB Enzyme Nomenclature

EC 2.6.1.118

Accepted name: [amino group carrier protein]-γ-(L-lysyl)-L-glutamate aminotransferase

Reaction: an [amino group carrier protein]-C-terminal-γ-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate

Other name(s): lysJ (gene name)

Systematic name: 2-oxoglutarate:[amino group carrier protein]-C-terminal-γ-(L-lysyl)-L-glutamate aminotransferase

Comments: The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Miyazaki, J., Kobashi, N., Nishiyama, M. and Yamane, H. Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through α-aminoadipate. J. Bacteriol. 183 (2001) 5067-5073. [PMID: 11489859]

2. Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T. and Nishiyama, M. Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat. Chem. Biol. 5 (2009) 673-679. [PMID: 19620981]

[EC 2.6.1.118 created 2019]


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