IUBMB Enzyme Nomenclature


Accepted name: homogentisate solanesyltransferase

Reaction: all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2

For diagram of reaction click here.

Glossary: 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol = 2-methyl-6-solanesylbenzene-1,4-diol = MSBQ

Other name(s): HST; PDS2 (gene name)

Systematic name: all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase

Comments: Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Sadre, R., Gruber, J. and Frentzen, M. Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis. FEBS Lett 580 (2006) 5357-5362. [PMID: 16989822]

2. Sadre, R., Frentzen, M., Saeed, M. and Hawkes, T. Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis. J. Biol. Chem. 285 (2010) 18191-18198. [PMID: 20400515]

[EC created 2014]

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