IUBMB Enzyme Nomenclature

EC 2.4.1.50

Accepted name: procollagen galactosyltransferase

Reaction: UDP-α-D-galactose + [procollagen]-(2S,5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(2S,5R)-5-O-(β-D-galactosyl)-5-hydroxy-L-lysine

Other name(s): hydroxylysine galactosyltransferase; collagen galactosyltransferase; collagen hydroxylysyl galactosyltransferase; UDP galactose-collagen galactosyltransferase; uridine diphosphogalactose-collagen galactosyltransferase; UDPgalactose:5-hydroxylysine-collagen galactosyltransferase; UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase; UDP-α-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase

Systematic name: UDP-α-D-galactose:[procollagen]-(2S,5R)-5-hydroxy-L-lysine 5-β-D-galactosyltransferase (configuration-inverting)

Comments: Probably involved in the synthesis of carbohydrate units in complement (cf EC 2.4.1.66 procollagen glucosyltransferase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-07-3

References:

1. Bosmann, H.B. and Eylar, E.H. Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen. Biochem. Biophys. Res. Commun. 33 (1968) 340-346. [PMID: 5722225]

2. Kivirikko, K.I. and Myllyla, R. In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.

3. Schegg, B., Hulsmeier, A.J., Rutschmann, C., Maag, C. and Hennet, T. Core glycosylation of collagen is initiated by two β(1-O)galactosyltransferases. Mol. Cell Biol. 29 (2009) 943-952. [PMID: 19075007]

[EC 2.4.1.50 created 1972, modified 1983]


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