IUBMB Enzyme Nomenclature

EC 2.4.1.322

Accepted name: devancosaminyl-vancomycin vancosaminetransferase

Reaction: dTDP-β-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin

For diagram of reaction click here.

Glossary: dTDP-β-L-vancosamine = dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-β-L-lyxo-hexopyranose

Other name(s): devancosaminyl-vancomycin TDP-vancosaminyltransferase; GtfD; dTDP-β-L-vancomycin:desvancosaminyl-vancomycin β-L-vancosaminetransferase; desvancosaminyl-vancomycin vancosaminetransferase

Systematic name: dTDP-β-L-vancomycin:devancosaminyl-vancomycin β-L-vancosaminetransferase

Comments: The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745-4755. [PMID: 11294642]

2. Mulichak, A.M., Lu, W., Losey, H.C., Walsh, C.T. and Garavito, R.M. Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry 43 (2004) 5170-5180. [PMID: 15122882]

[EC 2.4.1.322 created 2014]


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