IUBMB Enzyme Nomenclature


Accepted name: O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase

Reaction: transfers a β-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor

Other name(s): O-fucosylpeptide β-1,3-N-acetylglucosaminyltransferase; fringe

Systematic name: UDP-D-GlcNAc:O-L-fucosylpeptide 3-β-N-acetyl-D-glucosaminyltransferase

Comments: O-Fucosylpeptide 3-β-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 299203-70-6


1. Moloney, D.J., Panin, V.M., Johnston, S.H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K.D., Haltiwanger, R.S. and Vogt, T.F. Fringe is a glycosyltransferase that modifies Notch. Nature 406 (2000) 369-375. [PMID: ] 10935626]

[EC created 2002]

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