Reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
Glossary: a long-chain-fatty acid = a fatty acid with an aliphatic chain of 13-22 carbons.
Other name(s): FASN (gene name); fatty-acid synthase
Systematic name: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
Comments: The animal enzyme is a multi-functional protein catalysing the reactions of EC 188.8.131.52 [acyl-carrier-protein] S-acetyltransferase, EC 184.108.40.206 [acyl-carrier-protein] S-malonyltransferase, EC 220.127.116.11 β-ketoacyl-[acyl-carrier-protein] synthase I, EC 18.104.22.168 3-oxoacyl-[acyl-carrier-protein] reductase, EC 22.214.171.124 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 126.96.36.199 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 188.8.131.52 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 184.108.40.206, fatty-acyl-CoA synthase system.
Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, PDB, CAS registry number: 9045-77-6
1. Stoops, J.K., Ross, P., Arslanian, M.J., Aune, K.C., Wakil, S.J. and Oliver, R.M. Physicochemical studies of the rat liver and adipose fatty acid synthetases. J. Biol. Chem. 254 (1979) 7418-7426. [PMID: 457689]
2. Wakil, S.J., Stoops, J.K. and Joshi, V.C. Fatty acid synthesis and its regulation. Annu. Rev. Biochem. 52 (1983) 537-579. [PMID: 6137188]