IUBMB Enzyme Nomenclature

EC 2.3.1.275

Accepted name: acyl phosphate:glycerol-3-phosphate acyltransferase

Reaction: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycerol 3-phosphate + phosphate

Other name(s): plsY (gene name); G3P acyltransferase; GPAT; lysophosphatidic acid synthase; LPA synthase

Systematic name: acyl phosphoate:sn-glycerol 3-phosphate acyltransferase

Comments: The enzyme, found in bacteria, catalyses a step in the most widely distributed bacterial pathway for the initiation of phospholipid formation. The enzyme is membrane-bound.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Lu, Y.J., Zhang, Y.M., Grimes, K.D., Qi, J., Lee, R.E. and Rock, C.O. Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol. Cell 23 (2006) 765-772. [PMID: 16949372]

2. Yoshimura, M., Oshima, T. and Ogasawara, N. Involvement of the YneS/YgiH and PlsX proteins in phospholipid biosynthesis in both Bacillus subtilis and Escherichia coli. BMC Microbiol. 7 (2007) 69. [PMID: 17645809]

3. Lu, Y.J., Zhang, F., Grimes, K.D., Lee, R.E. and Rock, C.O. Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J. Biol. Chem 282 (2007) 11339-11346. [PMID: 17308305]

4. Hara, Y., Seki, M., Matsuoka, S., Hara, H., Yamashita, A. and Matsumoto, K. Involvement of PlsX and the acyl-phosphate dependent sn-glycerol-3-phosphate acyltransferase PlsY in the initial stage of glycerolipid synthesis in Bacillus subtilis. Genes Genet. Syst. 83 (2008) 433-442. [PMID: 19282621]

[EC 2.3.1.275 created 2018]


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