Reaction: (1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA
(2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA
For diagram of reaction click here.
Glossary: feruloylacetyl-CoA = feruloyl-diketide-CoA
(4-coumaroyl)acetyl-CoA = 4-coumaroyl-diketide-CoA
phenylpropanoylacetyl-CoA = phenylpropanoyl-diketide-CoA
Other name(s): phenylpropanoyl-diketide-CoA synthase; DCS
Systematic name: phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating)
Comments: The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Katsuyama, Y., Kita, T., Funa, N. and Horinouchi, S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J. Biol. Chem. 284 (2009) 11160-11170. [PMID: 19258320]