Reaction: malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2
For diagram of reaction click here.
Glossary: 2-hydroxybenzoyl-CoA = salicyloyl-CoA
Other name(s): BIS2; BIS3
Systematic name: malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
Comments: The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 18.104.22.168, biphenyl synthase) .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. A novel 4-hydroxycoumarin biosynthetic pathway. Plant Mol. Biol. 72 (2010) 17-25. [PMID: 19757094]