IUBMB Enzyme Nomenclature

EC 2.1.4.3

Accepted name: L-arginine:L-lysine amidinotransferase

Reaction: L-arginine + L-lysine = L-ornithine + L-homoarginine

Glossary: phaseolotoxin = N5-[amino(sulfoamino)phosphoryl]-L-ornithyl-L-alanyl-L-arginine

Other name(s): amtA (gene name)

Systematic name: L-arginine:L-lysine amidinotransferase

Comments: The enzyme, characterized from the bacterium Pseudomonas savastanoi pv. phaseolicola, is involved in the biosynthesis of the toxin phaseolotoxin, a modified tripeptide that causes the 'halo blight' disease of beans.

References:

1. Hernandez-Guzman, G. and Alvarez-Morales, A. Isolation and characterization of the gene coding for the amidinotransferase involved in the biosynthesis of phaseolotoxin in Pseudomonas syringae pv. phaseolicola. Mol. Plant Microbe Interact. 14 (2001) 545-554. [PMID: 11310742]

2. Li, M., Chen, L., Deng, Z. and Zhao, C. Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins. FEBS Open Bio 6 (2016) 603-609. [PMID: 27419063]

[EC 2.1.4.3 created 2019]


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