IUBMB Enzyme Nomenclature


Accepted name: mRNA (guanine-N7-)-methyltransferase

Reaction: S-adenosyl-L-methionine + a 5′-(5′-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA]

Glossary: a 5′-(5′-triphosphoguanosine)-[mRNA] = G5′ppp5’R-[mRNA]
a 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] = m7G5′ppp5’R-[mRNA] = cap0

Other name(s): messenger ribonucleate guanine 7-methyltransferase; guanine-7-methyltransferase; messenger RNA guanine 7-methyltransferase; S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

Systematic name: S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase

Comments: The nucleoside next to the terminal guanosine may be either guanosine or adenosine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 56941-25-4


1. Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. Proc. Natl. Acad. Sci. USA 72 (1975) 2525-2529. [PMID: 1058472]

2. Groner, Y., Gilbao, E. and Aviv, H. Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. Biochemistry 17 (1978) 977-982. [PMID: 629955]

3. Martin, S.A. and Moss, B. Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7)methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9330-9335. [PMID: 76069264]

4. Martin, S.A., Paoletti, E. and Moss, B. Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions. J. Biol. Chem. 250 (1975) 9322-9329. [PMID: 1194287]

[EC created 1981]

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