Reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
Glossary entries:
Melatonin: N-acetyl-5-methoxytryptamine
Serotonin: 5-hydroxytryptamine
Tryptamine: 2-(1H-indol-3-yl)ethanamine
Other name(s): hydroxyindole methyltransferase; hydroxyindole O-methyltransferase; N-acetylserotonin O-methyltransferase; acetylserotonin methyltransferase
Systematic name: S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
Comments: Some other hydroxyindoles also act as acceptor, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-77-0
References:
1. Axelrod, J. and Weissbach, H. Purification and properties of hydroxyindole-O-methyl transferase. J. Biol. Chem. 236 (1961) 211-213.