Reaction: a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) tetramethylammonium-specific corrinoid protein]
Glossary: CoM = coenzyme M = 2-mercaptoethanesulfonate
Other name(s): methyltransferase 2 (ambiguous); mtqA (gene name)
Systematic name: methylated tetramethylammonium-specific corrinoid protein:Coenzyme M methyltransferase
Comments: The enzyme, which is involved in methanogenesis from tetramethylammonium, catalyses the transfer of a methyl group from a corrinoid protein (see EC 18.104.22.168, tetramethylammonium—corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC 22.214.171.124, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Asakawa, S., Sauer, K., Liesack, W. and Thauer, R.K. Tetramethylammonium:coenzyme M methyltransferase system from methanococcoides s. Arch. Microbiol. 170 (1998) 220-226. [PMID: 9732435]