IUBMB Enzyme Nomenclature

EC 2.1.1.221

Accepted name: tRNA (guanine9-N1)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine9 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA

Other name(s): Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; tRNA (guanine-N(1)-)-methyltransferase; tRNA m1G9-methyltransferase; tRNA m1G9 MTase

Systematic name: S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase

Comments: The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Kempenaers, M., Roovers, M., Oudjama, Y., Tkaczuk, K.L., Bujnicki, J.M. and Droogmans, L. New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA. Nucleic Acids Res. 38 (2010) 6533-6543. [PMID: 20525789]

2. Jackman, J.E., Montange, R.K., Malik, H.S. and Phizicky, E.M. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. RNA 9 (2003) 574-585. [PMID: 12702816]

[EC 2.1.1.221 created 2011 (EC 2.1.1.31 created 1971, part transferred 2011 to EC 2.1.1.221)]


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