Reaction: S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
Other name(s): (m2G10) methyltransferase; Trm11-Trm112 complex
Systematic name: S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase
Comments: In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Purushothaman, S.K., Bujnicki, J.M., Grosjean, H. and Lapeyre, B. Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol. Cell Biol. 25 (2005) 4359-4370. [PMID: 15899842]