Reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+
Other name(s): coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH2:CoA-glutathione oxidoreductase
Systematic name: glutathione:NADP+ oxidoreductase (CoA-acylating)
Comments: A flavoprotein. The substrate is a mixed disulfide. May be identical to EC 220.127.116.11, thioredoxin-disulfide reductase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37256-33-0
1. Ondarza, R.N., Abney, R. and López-Colomé, A.M. Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast. Biochim. Biophys. Acta 191 (1969) 239-248. [PMID: 4390951]
2. Ondarza, R.N., Escamilla, E., Gutierrez, J. and De la Chica, G. CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity. Biochim. Biophys. Acta 341 (1974) 162-171. [PMID: 4151341]
3. Carlberg, I. and Mannervik, B. Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione. Biochim. Biophys. Acta 484 (1977) 268-274. [PMID: 334266]