IUBMB Enzyme Nomenclature

EC 1.5.1.25

Accepted name: thiomorpholine-carboxylate dehydrogenase

Reaction: thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+

For diagram of reaction click here.

Other name(s): ketimine reductase; ketimine-reducing enzyme

Systematic name: thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase

Comments: The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 115232-54-7

References:

1. Nardini, M., Ricci, G., Caccuri, A.M., Solinas, S.P., Vesci, L. and Cavallini, D. Purification and characterization of a ketimine-reducing enzyme. Eur. J. Biochem. 173 (1988) 689-694. [PMID: 3371353]

[EC 1.5.1.25 created 1990]


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