IUBMB Enzyme Nomenclature


Accepted name: pseudooxynicotine oxidase

Reaction: 4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O + O2 = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2

Glossary: 4-(methylamino)-1-(pyridin-3-yl)butan-1-one = pseudooxynicotine
4-oxo-4-(pyridin-3-yl)butanal = 3-succinoylsemialdehyde-pyridine

Systematic name: 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing)

Comments: Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine. Appl. Environ. Microbiol. 78 (2012) 2154-2160. [PMID: 22267672]

[EC created 2012]

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