Reaction: (2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+
Other name(s): 2,4-diaminopentanoic acid C4 dehydrogenase
Systematic name: (2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Comments: Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 39346-26-4
References:
1. Somack, R. and Costilow, R.N. 2,4-Diaminopentanoic acid C4 dehydrogenase. Purification and properties of the protein. J. Biol. Chem. 248 (1973) 385-388. [PMID: 4684685]
2. Stadtman, T.C. Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase). Adv. Enzymol. Relat. Areas Mol. Biol. 38 (1973) 441-445.
3. Tsuda, Y. and Friedmann, H.C. Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide. J. Biol. Chem. 245 (1970) 5914-5926. [PMID: 4394942]