IUBMB Enzyme Nomenclature


Accepted name: protoporphyrinogen IX dehydrogenase (menaquinone)

Reaction: protoporphyrinogen IX + 3 menaquinone = protoporphyrin IX + 3 menaquinol

Other name(s): HemG

Systematic name: protoporphyrinogen IX:menaquinone oxidoreductase

Comments: This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Boynton, T.O., Daugherty, L.E., Dailey, T.A. and Dailey, H.A. Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity. Biochemistry 48 (2009) 6705-6711. [PMID: 19583219]

[EC created 2010]

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