Reaction: geissoschizine + NADP+ = 4,21-didehydrogeissoschizine + NADPH
Systematic name: geissoschizine:NADP+ 4,21-oxidoreductase
Comments: Involved in the interconversion of heteroyohimbine alkaloids in Catharanthus roseus.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 84399-94-0
References:
1. Pfitzner, A. and Stöckigt, J. Partial-purification and characterization of geissoschizine dehydrogenase from suspension-cultures of Catharanthus roseus. Phytochemistry 21 (1982) 1585-1588.