Reaction: 4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
Other name(s): p-hydroxybenzaldehyde dehydrogenase (ambiguous); pchA (gene name)
Systematic name: 4-hydroxybenzaldehyde:NADP+ oxidoreductase
Comments: Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 126.96.36.199, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Whited, G.M. and Gibson, D.T. Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1. J. Bacteriol. 173 (1991) 3017-3020. [PMID: 2019564]
2. Chen, Y.F., Chao, H. and Zhou, N.Y. The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866. Appl. Microbiol. Biotechnol. 98 (2014) 1349-1356. [PMID: 23736872]