Reaction: 5-oxopentanoate + NADP+ + H2O = glutarate + NADPH + H+
Glossary: 5-oxopentanoate = glutarate semialdehyde
Other name(s): glutarate semialdehyde dehydrogenase; davD (gene name)
Systematic name: glutarate-semialdehyde:NADP+ oxidoreductase
Comments: The enzyme, characterized from multiple Pseudomonas strains, participates in L-lysine degradation. Unlike earlier claims, it prefers NADP+ to NAD+.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9028-99-3
References:
1. Ichihara, A. and Ichihara, E.A. Metabolism of L-lysine by bacterial enzymes. V. Glutaric semialdehyde dehydrogenase. J. Biochem. (Tokyo) 49 (1961) 154-157. [PMID: 13717359]
2. Chang, Y. F. and Adams, E. Glutaric semialdehyde dehydrogenase (Pseudomonas putida). Methods Enzymol. 17B (1971) 166-171.
3. Fothergill, J.C. and Guest, J.R. Catabolism of L-lysine by Pseudomonas aeruginosa. J. Gen. Microbiol. 99 (1977) 139-155. [PMID: 405455]
4. Chang, Y.F. and Adams, E. Glutarate semialdehyde dehydrogenase of Pseudomonas. Purification, properties, and relation to L-lysine catabolism. J. Biol. Chem. 252 (1977) 7979-7986. [PMID: 914857]
5. Yamanishi, Y., Mihara, H., Osaki, M., Muramatsu, H., Esaki, N., Sato, T., Hizukuri, Y., Goto, S. and Kanehisa, M. Prediction of missing enzyme genes in a bacterial metabolic network. Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa. FEBS J. 274 (2007) 2262-2273. [PMID: 17388807]