IUBMB Enzyme Nomenclature


Accepted name: aquacobalamin reductase (NADPH)

Reaction: 2 cob(II)alamin + NADP+ + 2 H2O = 2 aquacob(III)alamin + NADPH + H+

Other name(s): aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase; NADPH-linked aquacobalamin reductase; NADPH2:aquacob(III)alamin oxidoreductase

Systematic name: cob(II)alamin:NADP+ oxidoreductase

Comments: A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 110777-32-7


1. Watanabe, F., Oki, Y., Nakano, Y. and Kitaoka, S. Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis. J. Biol. Chem. 262 (1987) 11514-11518. [PMID: 3114247]

2. Watanabe, F., Yamaji, R., Isegawa, Y., Yamamoto, T., Tamura, Y. and Nakano, Y. Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis. Arch. Biochem. Biophys. 305 (1993) 421-427. [PMID: 8373179]

[EC created 1989 as EC, transferred 2002 to EC]

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