IUBMB Enzyme Nomenclature


Accepted name: aquacobalamin reductase

Reaction: 2 cob(II)alamin + NAD+ + 2 H2O = 2 aquacob(III)alamin + NADH + H+

Other name(s): aquocobalamin reductase; vitamin B12a reductase; NADH-linked aquacobalamin reductase; B12a reductase; NADH2:cob(III)alamin oxidoreductase

Systematic name: cob(II)alamin:NAD+ oxidoreductase

Comments: A flavoprotein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37256-39-6


1. Walker, G.A., Murphy, S. and Huennekens, F.M. Enzymatic conversion of vitamin B12a to adenosyl-B12: evidence for the existence of two separate reducing systems. Arch. Biochem. Biophys. 134 (1969) 95-102. [PMID: 4390543]

[EC created 1972 as EC, transferred 2002 to EC]

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