Reaction: 2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H
Other name(s): ferric reductase (ambiguous)
Systematic name: Fe(II)-siderophore:NAD(P)+ oxidoreductase
Comments: A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 18.104.22.168, ferric-chelate reductase (NADH) and EC 22.214.171.124, ferric-chelate reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Vadas, A., Monbouquette, H.G., Johnson, E. and Schroder, I. Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus. J. Biol. Chem. 274 (1999) 36715-36721. [PMID: 10593977]
2. Chiu, H.J., Johnson, E., Schroder, I. and Rees, D.C. Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+. Structure 9 (2001) 311-319. [PMID: 11525168]