Reaction: 2 superoxide + 2 H+ = O2 + H2O2
Glossary: superoxide = O2•–
Other name(s): superoxidase dismutase; copper-zinc superoxide dismutase; Cu-Zn superoxide dismutase; ferrisuperoxide dismutase; superoxide dismutase I; superoxide dismutase II; SOD; Cu,Zn-SOD; Mn-SOD; Fe-SOD; SODF; SODS; SOD-1; SOD-2; SOD-3; SOD-4; hemocuprein; erythrocuprein; cytocuprein; cuprein ; hepatocuprein
Systematic name: superoxide:superoxide oxidoreductase
Comments: A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9054-89-1
References:
1. Keele, B.B., McCord, J.M. and Fridovich, I. Further characterization of bovine superoxide dismutase and its isolation from bovine heart. J. Biol. Chem. 246 (1971) 2875-2880. [PMID: 4324341]
2. Sawada, Y., Ohyama, T. and Yamazaki, I. Preparation and physicochemical properties of green pea superoxide dismutase. Biochim. Biophys. Acta 268 (1972) 305-312. [PMID: 4337330]
3. Vance, P.G., Keele, B.B. and Rajagopalan, K.V. Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. J. Biol. Chem. 247 (1972) 4782-4786. [PMID: 4559499]