IUBMB Enzyme Nomenclature

EC 1.14.99.19

Accepted name: plasmanylethanolamine desaturase

Reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced acceptor + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O

Other name(s): alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; dehydrogenase, alkyl-acylglycerophosphorylethanolamine; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase

Systematic name: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase

Comments: Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 39391-13-4

References:

1. Paltauf, F. and Holasek, A. Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine. J. Biol. Chem. 248 (1973) 1609-1615. [PMID: 4144394]

2. Wykle, R.L., Blank, M.L., Malone, B. and Snyder, F. Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine. J. Biol. Chem. 247 (1972) 5442-5447. [PMID: 4403444]

[EC 1.14.99.19 created 1976]


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