Reaction: anthranilate + tetrahydrobiopterin + O2 = 3-hydroxyanthranilate + dihydrobiopterin + H2O
Other name(s): anthranilate 3-hydroxylase; anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase
Systematic name: anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Comments: Requires Fe2+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37256-79-4
1. Jequier, E., Robinson, B.S., Lovenberg, W. and Sjoerdsma, A. Further studies on tryptophan hydroxylase in rat brainstem and beef pineal. Biochem. Pharmacol. 18 (1969) 1071-1081. [PMID: 5789774]
2. Nair, P.M. and Vaidyanathan, C.S. Anthranilic acid hydroxylase from Tecoma stans. Biochim. Biophys. Acta 110 (1965) 521-531.