Reaction: questin + NADPH + H+ + O2 = demethylsulochrin + NADP+
Glossary: questin = 3,8-dihydroxy-1-methoxy-6-methylanthracene-9,10-dione
demethylsulochrin = 2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoic acid
Other name(s): questin oxygenase
Systematic name: questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)
Comments: The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 115232-45-6
1. Fujii, I., Ebizuka, Y. and Sankawa, U. A novel anthraquinone ring cleavage enzyme from Aspergillus terreus. J. Biochem. (Tokyo) 103 (1988) 878-883. [PMID: 3182756]