Reaction: (1) dimethyl sulfide + NADH + H+ + O2 = dimethyl sulfoxide + NAD+ + H2O
(2) dimethyl sulfoxide + NADH + H+ + O2 = dimethyl sulfone + NAD+ + H2O
For diagram of reaction click here.
Other name(s): dsoBCDEF (gene names)
Systematic name: dimethyl sulfide,NADH:oxygen oxidoreductase (S-oxidizing)
Comments: The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC 126.96.36.199, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism.
Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:
1. Horinouchi, M., Kasuga, K., Nojiri, H., Yamane, H. and Omori, T. Cloning and characterization of genes encoding an enzyme which oxidizes dimethyl sulfide in Acinetobacter sp. strain 20B. FEMS Microbiol. Lett. 155 (1997) 99-105. [PMID: 9345770]
2. Horinouchi, M., Yoshida, T., Nojiri, H., Yamane, H. and Omori, T. Polypeptide requirement of multicomponent monooxygenase DsoABCDEF for dimethyl sulfide oxidizing activity. Biosci. Biotechnol. Biochem. 63 (1999) 1765-1771. [PMID: 26300166]