Reaction: (S)-lactate + oxaloacetate = pyruvate + malate
Other name(s): malate-lactate transhydrogenase
Systematic name: (S)-lactate:oxaloacetate oxidoreductase
Comments: Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 9077-15-0
References:
1. Allen, S.H.G. The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus. J. Biol. Chem. 241 (1966) 5266-5275. [PMID: 4289051]
2. Allen, S.H.G. and Patil, J.R. Studies on the structure and mechanism of action of the malate-lactate transhydrogenase. J. Biol. Chem. 247 (1972) 909-916. [PMID: 4333516]