IUBMB Enzyme Nomenclature

EC 1.1.2.3

Accepted name: L-lactate dehydrogenase (cytochrome)

Reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+

Other name(s): lactic acid dehydrogenase; cytochrome b2 (flavin-free derivative of flavocytochrome b2); flavocytochrome b2; L-lactate cytochrome c reductase; L(+)-lactate:cytochrome c oxidoreductase; dehydrogenase, lactate (cytochrome); L-lactate cytochrome c oxidoreductase; lactate dehydrogenase (cytochrome); lactic cytochrome c reductase

Systematic name: (S)-lactate:ferricytochrome-c 2-oxidoreductase

Comments: Identical with cytochrome b2; a flavohemoprotein (FMN).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9078-32-4

References:

1. Appleby, C.A. and Morton, R.K. Lactic dehydrogenase and cytochrome b2 of baker's yeast. Purification and crystallization. Biochem. J. 71 (1959) 492-499. [PMID: 13638255]

2. Appleby, C.A. and Morton, R.K. Lactic dehydrogenase and cytochrome b2 of baker's yeast. Enzymic and chemical properties of the crystalline enzyme. Biochem. J. 73 (1959) 539-550. [PMID: 13793977]

3. Bach, S.G., Dixon, M. and Zerfas, L.G. Yeast lactic dehydrogenase and cytochrome b2. Biochem. J. 40 (1946) 229-239. [PMID: 16747991]

4. Nygaard, A.P. Lactate dehydrogenases of yeast. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol.7, Academic Press, New York, 1963, p. 557-565.

[EC 1.1.2.3 created 1961]


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