Reaction: (S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+
Other name(s): MdH II, NAD(P)+-dependent malate dehyrogenase
Systematic name: (S)-malate:NAD(P)+ oxidoreductase
Comments: This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity . Different from EC 18.104.22.168 [malate dehydrogenase (NAD+)], EC 22.214.171.124 [malate dehydrogenase (NADP+)] and EC 126.96.36.199 [malate dehydrogenase (quinone)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Thompson, H., Tersteegen, A., Thauer, R.K. and Hedderich, R. Two malate dehydrogenases in Methanobacterium thermoautotrophicum. Arch. Microbiol. 170 (1998) 38-42. [PMID: 9639601]