Reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+
For diagram click here.
Systematic name: 10-deoxysarpagine:NADP+ oxidoreductase
Comments: Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 86777-26-6
1. Pfitzner, A., Krausch, B. and Stöckigt, J. Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine. Tetrahedron 40 (1984) 1691-1699.