Reaction: N-acetyl-α-D-glucosamine + NAD+ = N-acetyl-D-glucosaminate + NADH + H+
Other name(s): N-acetylhexosamine dehydrogenase; N-acetyl-D-hexosamine dehydrogenase
Systematic name: N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase
Comments: Also acts on N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Anomeric specificity was tested with N-acetyl-D-glucosamine, and it was shown that the enzyme is specific for the α anomer.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 122785-18-6
References:
1. Horiuchi, T. and Kurokawa, T. Purification and characterization of N-acetyl-D-hexosamine dehydrogenase from Pseudomonas sp no 53. Agric. Biol. Chem. 53 (1989) 1919-1925.