Reaction: androsterone + NAD(P)+ = 5α-androstane-3,17-dione + NAD(P)H + H+
Other name(s): 3(17)α-hydroxysteroid dehydrogenase
Systematic name: 3(or 17)α-hydroxysteroid:NAD(P)+ oxidoreductase
Comments: Acts on the 3α-hydroxy group of androgens of the 5α-androstane series; and also, more slowly, on the 17α-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)β-hydroxysteroid dehydrogenase).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 83294-77-3
References:
1. Lau, P.C.K., Layne, D.S. and Williamson, D.G. A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme. J. Biol. Chem. 257 (1982) 9444-9449. [PMID: 6955302]
2. Lau, P.C.K., Layne, D.S. and Williamson, D.G. Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver. J. Biol. Chem. 257 (1982) 9450-9456. [PMID: 6955303]