Research
Small molecule

αvβ6 inhibiting peptide permits diagnostic imaging and delivery of anticancer therapy

Description and applications

αvβ6 is a major new target for molecular-specific imaging and therapy of cancer. It is expressed only on epithelia and then usually only during processes of tissue remodelling; these include wound healing, chronic inflammation, and cancer. The αvβ6 inhibiting peptide could not only permit diagnostic imaging, but also to deliver anticancer therapy specifically to tumour cells while sparing local normal tissues.

Publications

Saha et al. 2010. J Pathol. 222(1):52-63. PMID: 20629113.

Keywords

Intergrins, cancer, αvβ6

Prof John Marshall

Barts Cancer Institute

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