Research
Animal model

The Zebrafish Facility at QMUL

Description and applications

The Zebrafish Facility at QMUL houses and provides zebrafish at all stages of development for cell biological, developmental or behavioural analysis. We maintain Home Office Licences allowing the receipt and maintenance of a wide range of mutant and transgenic lines. We are equipped with injection and microscope facilities for cell transplant or RNA/DNA expression analyses and the generation of TALEN and CRISPR lines. We have custom built equipment and software for behavioural analysis of larval and adult stages.

Publications

Parker MO, Brock AJ, Sudwarts A, Brennan CH. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.Psychopharmacology (Berl) (2014) Psychopharmacology: Volume 231, Issue 13 (2014), Page 2671-2679 DOI 10.1007/s00213-014-3439-z

Parker MO, Ife D, Ma J, Pancholi M, Straw C, Smeraldi F , Brennan CH. Development and automation of a test of impulse control in zebrafish. Frontiers in Systems neuroscience (2013) 7: p. 65. DOI: 10.3389/fnsys.2013.00065

MA Cichon, Z Szentpetery, MP Caley, ES Papadakis, IC Mackenzie, CH Brennan and EA O'Toole. The receptor tyrosine kinase Axl regulates cell/cell adhesion and stemness in cutaneous squamous cell carcinoma. Oncogene (2013), 4185-92. doi: 10.1038/onc.2013.388.

Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR, Crnogorac-Jurcevic T. AGR2 is a Novel Surface Antigen that Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D. Cancer Res 71(22):7091-7102

Keywords

developmental biology, cancer, cell transplant, CRISPR, behaviour, GFP transgenic lines

Dr Caroline Brennan

School of Biological and Chemical Sciences

Want access?

Get in touch with the Business Development Office smd-qmbusiness@qmul.ac.uk