Description and applications

Mouse antibody against human BCRABL (Subclass: IgG2a). Immunogen: BCR-ABL peptide

The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.

Applications: IHC IF RIA

Publications

Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.
Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.
Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.

Keywords

acute lymphocytic leukemia, chronic myeloid leukemia, cancer, BCR-ABL

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