Research
Antibody

Specificity: Human; Applications: IHC IF WB

Description and applications

Mouse antibody against Human Keratin 8 (Subclass: IgG2b)

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. Keratin 8 is the tissue polypeptide antigen (TPA) reported to be present in the serum of cancer patients.

Applications:  IHC IF WB

Commercially available at Research and Diagnostics Systems

Publications

Waseem et al. 2004. Biochemistry. 43(5):1283-95. PMID: 14756564.
Godsave et al. 1986. J Embryol Exp Morphol. 97:201-23. PMID: 2432146.

Lane et al. 1985. Ann N Y Acad Sci. 455:241-58. PMID: 2417515.

Keywords

Antibody, Keratin 8, keratinocyte, epithelium, adenocarcinoma

Prof Irene Leigh

Previously at Blizard Institute

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