Research
Antibody

Specificity: Human; Applications: IHC IF IP WB

Description and applications

1-  Mouse antibody against Human Keratin 16 (Subclass: IgG1)

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 16 is expressed in suprabasal keratinocytes of wounded epidermis. Keratin 16 suprabasal expression is found in situations of high cell turnover. LL025 reactivity was completely negative in normal breast tissue and non-invasive breast carcinoma. However, 10% of the invasive carcinomas tested were diffusely or focally positive with this antibody.

Applications:  IHC IF IP WB

Commercially available at Abcam

Publications

Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.
de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.  
Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.  
Wetzels et al. 1991. Am J Pathol. 138(3):751-63. PMID: 1705754.
Hughes BR et al. 1996. Br. J. Dermatol. 134(2):247-56.PMID: 8746337.

Keywords

Antibody, Keratin 16, epithelium, tissue differentiation, keratinocyte

Prof Irene Leigh

Previously at Blizard Institute

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